Results
| PMID | 26411218 |
| Gene Name | CHI3L1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 63 |
| Population details | 63 (33 endometriosis patients, 30 healthy controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Clin Exp Obstet Gynecol. 2015;42(4):495-7. Ural, U Mete| Tekin, Y Bayoglu| Cure, M| Sahin, F Kir PURPOSE: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. MATERIALS AND METHODS: This was a cross-sectional clinical study conducted in a tertiary care center. Demographics and serum YKL levels were determined and noted in a total of 63 cases (33 endometriosis patients, 30 healthy controls). Measurement of YKL-40 levels was made using a YKL-40 enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's protocol. RESULTS: The mean serum YKL-40 levels of the patient group was 106.0 +/- 15.9 (range 23.44 to 382.55) years, while the mean serum YKL-40 levels of the controls was 52.2 +/- 7.0 (range 22.35 to 160.0) years (p = 0.003). CONCLUSIONS: This is the first study evaluating serum YKL-40 levels in endometriosis. The present results indicate that YKL-40 levels were increased in patients with endometriosis compared to controls. The authors propose that circulating YKL-40 levels could be a novel biomarker for diagnosis and follow-up of endometriosis. Mesh Terms: Adipokines/*blood/immunology| Adult| Biomarkers/*blood| Case-Control Studies| Chitinase-3-Like Protein 1| Cross-Sectional Studies| Endometriosis/*blood| Enzyme-Linked Immunosorbent Assay| Female| Humans| Lectins/*blood/immunology|DA 2015/10/31 0 |
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